EXPOSURE TO ELEVATED GLUCOCORTICOID DURING DEVELOPMENT PRIMES ALTERED TRANSCRIPTIONAL RESPONSES TO ACUTE STRESS IN ADULTHOOD

Exposure to elevated glucocorticoid during development primes altered transcriptional responses to acute stress in adulthood

Summary: Early life stress (ELS) is a major risk factor for developing psychiatric disorders, with glucocorticoids (GCs) implicated in mediating its effects in shaping adult phenotypes.In this process, exposure to high levels of developmental GC (hdGC) is thought to induce molecular changes Tub Sealing Gasket that prime differential adult responses

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Impact of Expression and Genetic Variation of microRNA-34b/c on Cognitive Dysfunction in Patients with Major Depressive Disorder

Ning Sun,1,2 Chunxia Yang,1 Xiaoting He,1,3 Zhifen Liu,1 Sha Liu,1 Xinrong Li,1 Yanfang Wang,1 Ruihua Jin,2 Kerang Zhang1 1Department of Psychiatry, First Hospital of Shanxi Medical University, Taiyuan, People’s Republic of China; 2Nursing College of Shanxi Medical University, Taiyuan, People’s Republic of China; 3University-Town Hospit

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